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ACE2, COVID19 and serum ACE as a possible biomarker to predict severity of disease

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Elsevier hereby grants permission to make all its COVIDrelated research that is available on the COVID resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source.

This article has been cited by other articles in PMC. Preliminary epidemiological data indicates that symptomatic Coronavirus disease COVID in children is uncommon. This could suggest that children are less susceptible to infection, or that infection in children leads to asymptomatic or mild disease that remains largely undetected.

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This raises the possibility that susceptibility to infection is related to expression of the target ACE2 receptor in virally exposed epithelium [ 2 ]. Children have higher ACE volumes silicon antirid serum than adults [ 5 ].

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It remains to be verified if the low frequency of symptomatic COVID in children and adolescents can be attributed to lower levels of membrane bound ACE2 in this population. The hypothesis that serum ACE could serve as a biomarker for the severity of COVID therefore hinges on the data being able to draw a line between the propositions outlined above.

Am fost atât de impresionat încât a trebuit să citesc mort-copt orice carte despre Hagakure pe care o puteam găsi în librării. Dar, bineînțeles, nu se tipăresc la noi cărțile valoroase. Totuși am fost norocos să găsesc o lucrare despre Calea samuraiului, a lui Yukio Mishima, tradusă din engleză, nu din japoneză. Părerile lui Mishima pe marginea sfaturilor din Hagakure sunt destul de interesante. Puteam trăi și fără ele.

Should such a relationship be established, it could provide us with a powerful tool for early intervention in and triage of COVID patients. Low levels of circulating ACE in symptomatic patients could predict mild disease, whereas high levels could be indicative of a more severe progression, cf.

Original publication This work contains previously unpublished material and is not being considered for publication elsewhere.

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Funding sources None. Compliance with ethical standards As this letter presents a theoretical hypothesis and contains no patient data, approval from the regional committees for medical and health research ethics in Norway was not required. Declaration of Competing Interest The author declares no conflict of interest.

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Acknowledgements I play anti-aging primer review like to thank my colleagues for their support and for providing a fertile environment for discussing ideas and theories.

References 1. Wan Y. Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS.

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Kuba K. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases. Rodriguez G.

Serum play anti-aging primer review enzyme activity in normal children and in those with sarcoidosis.

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